Diabetrol - 5 + 500mg

This drug has a generic name Glibenclamide Metformin which is a combination oral form medicine to treat type2 diabetes. It is made up of two active ingredients Glibenclamide and Metformin which are also available as individual drugs for the treatment of diabetes.

It is sold under various trade names across worldwide including Glucovance and Diabetrol (by Nicholas Pharma). Glibenclamide and Metformin helps in type 2 diabetes treatment by making the body control its blood sugar level. It is not recommended for type-1 diabetes and it may also be prescribed for other treatments which are not listed here.

Important information about Glibenclamide Metformin

You should avoid the use of this medicine, if you are allergic to it, or if you are suffering from diabetic ketoacidosis (a condition in which body lacks insulin level and employ fats in the place of glucose for energy purposes that result in ketones in the body). You may be advised to temporarily stop this medicine if you are scheduled for an X-Ray or CT scan test and require a dye to be injected intravenously. 

Prior taking this medicine, you should inform your doctor if you have liver or heart disease, an incident of heart attack or stroke in the past, or an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD). Lactic acidosis has been observed in people who take Glibenclamide and Metformin. Get medical care immediately if you witness the symptoms of Lactic acidosis such as muscle pain or weakness, numb or cold feeling in your limbs, breathing trouble, pain, nausea with vomiting, slow or irregular heartbeat, dizziness, overall weakness, or lethargy. Early symptoms may deteriorate and can leads to fatal condition. So, be careful and ask your doctor about more details.

Before taking Glibenclamide Metformin

Before taking Glibenclamide Metformin, take care of all the precautions mentioned above. Discuss all the conditions with your doctor and clear all the doubts pertaining to this drug.  It belongs to FDA pregnancy category B drug. It is not expected that it could harm an unborn baby while taken during the pregnancy. Severe hypoglycemia has been seen in babies whose mothers have taken similar medicine for diabetes at the nearby time of delivery. It is also unknown whether it could pass into the breast milk and harm your nursing baby. Consult your doctor about taking this medicine during pregnancy.

Some oral form of diabetes medicine may cause the serious heart ailments. However, untreated diabetes may damage the heart and other organs. Discuss the benefits of Glibenclamide Metformin and diabetes treatment with your doctor to obtain the positive effects.

Dosage information

It is very important to follow your doctor’s instruction while taking this medicine. Never stop taking this medicine until your doctor advices you to do so. Take the medicine about the same time each day because it is the best practice to remember when to take the drug. Do not alter the dosage unless your doctor advises you to do so. Also, do not take this medicine after the prescription period is over. You must take Glibenclamide Metformin with meal or according to your doctor’s advice. While taking this medicine, you must keep an eye on your blood sugar levels, especially if you skip your meals, exercise more, have an illness or infection, or drink alcohol. You may also require undergoing several blood tests to closely monitor your diabetes. Don’t skip any of these tests.

Taking Glibenclamide and Metformin may lead to hypoglycemia or low blood sugar level in the body. The symptoms correspond to Hypoglycemia are as follows: headache, hunger, weakness, tremors, sweating, irritability, concentrating trouble. Keep a source of sugar like candy, glucose tablets or gel handy with you. If you experience serious hypoglycemia and can’t eat or drink, you may be required to take glucose injections called glucagon which can self administer. Ask your doctor upon this condition.   

This medicine will not control your diabetic problems single handedly, you have to follow strict dieting schedule, exercises and weight control measures and other complimentary medicines. Store the medicine in a cool or dry place.

Note: Glibenclamide and Metformin dosage may depend on certain factors including age, sex, drug allergies, or seriousness of the condition among several other factors. Your dosage may determined by your physician after examining you properly.    

What if you miss a dose

If you miss a dose of Glibenclamide and Metformin, take the dose as soon as you remember, but take it with some food. Be aware to skip the dose if the next dose time is almost up. Taking multiple dose can lead to excess medicine in your body which might cause harmful conditions.     

What if you overdose

In case of overdose, get emergency medical help or call your doctor immediately. Overdose may result in lactic acidosis and hypoglycemia. Symptoms of lactic acidosis are: chills, muscle pain, breathing shortness, light headed feeling, feeling like you may pass out, stomach ache, increased sleepiness, or reduced heart rate.
Symptoms of severe hypoglycemia are: blurred vision, severe lethargy, sweating, speech troubles, tremors, confusion, pain in stomach, and convulsions (seizure).

Things to avoid

You should strictly avoid the consumption of alcohol as alcohol can drastically reduce your blood sugar level which can be harmful and can lead to lactic acidosis.

Side Effects

Side effects caused by Glibenclamide and Metformin medication (Glucovance, Diabetrol) are hives, breathing difficulty, swelling in face, lips, tongue, or throat. Seek medical care immediately in case you experience following symptoms chills, muscle pain, breathing shortness, light headed feeling, feeling like you may pass out, stomach ache, increased sleepiness, or reduced heart rate.  Immediately stop using this medicine if you get following serious side effects: dark colored urine, pale or yellow skin, weakness, confusion, nausea, upper stomach pain, itching, appetite loss, clay colored stools, or jaundice. While, some less serious side effects are runny nose, sneezing, headache, symptoms of cold, headache, mild dizziness, mild nausea or vomiting, upset stomach, or diarrhea. The side effects of Glibenclamide and Metformin mentioned above are not only the ones, there may be some others. Call your doctor right away and get the medical attention immediately if you experience these side effects.

Interaction with other drugs

Notify your doctor if you are taking other medicines like: nifedipine, cimetidine, ranitidine, furosemide, digoxin, vancomycin, quinidine, vancomycin, trimethoprim, quinine, morphine, or amiloride. They can interfere with this medication significantly. You may get hypoglycemia, if you if you take Glibeclamide and Metformin with these medications: diuretics; isoniazid; steroids; birth control pills and other hormones; diet pills or medicines to treat asthma, colds or allergies; thyroid medicine; niacin; or phenothiazines. You may experience hypoglycemia (low blood sugar) if you take Glibenclamide and Metformin with these medications: exenatide; some nonsteroidal anti-inflammatory drugs; aspirin or other salicylates; exenatide; sulfa drugs; a monoamine oxidase inhibitor; other oral diabetes medications like acarbose, metformin, miglitol, rosiglitazone or others. The above mentioned lists of drugs which can interact with Glibenclamide and Metformin are non exhaustive and there may be some other drugs which interrupt the functioning of Glibenclamide and Metformin thereby increasing or reducing its effects of lowering your blood sugar level. Inform your doctor about all medications which you are using prescribed or OTC or herbal products, before taking Glibenclamide and Metformin. Never start taking a new medicine without your doctor’s advice.

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